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In a fast moving technology industry having been able to use the same tool for
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At this point, each bound sequence exists as a single copy, which produces too faint a signal to detect reliably. Colony sequencing solves this by generating clusters of identical fragments through a process called bridge amplification. The adapter on the free end of each DNA strand will be complementary to some of the original, short sequences on the DNA lawn, and when this binding occurs, the strand bends over to form a bridge shape. Another round of amplification takes place, resulting in two complementary strands each directly affixed to the flow cell. This “bridge amplification” process is repeated over and over to propagate the sequence.
As you can see, they are totally unrelated to each other. It means that according to the High Cohesion pattern, the code responsible for each of them should not reside together.
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