This fragmentation hurts portability. Code that performs well on one runtime may behave differently (or poorly) on another, even though it's using "standard" APIs. The complexity burden on runtime implementers is substantial, and the subtle behavioral differences create friction for developers trying to write cross-runtime code, particularly those maintaining frameworks that must be able to run efficiently across many runtime environments.
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The word “isolation” gets used loosely. A Docker container is “isolated.” A microVM is “isolated.” A WebAssembly module is “isolated.” But these are fundamentally different things, with different boundaries, different attack surfaces, and different failure modes. I wanted to write down my learnings on what each layer actually provides, because I think the distinctions matter and allow you to make informed decisions for the problems you are looking to solve.